Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective

doi:10.1016/j.meegid.2020.104440

	Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective
	Uddin, Md Bashir; Hasan, Mahmudul; Imran, Md Abdus Shukur; Harun-Al-Rashid, Ahmed; Ahsan, Md Irtija; Ahmed, Syed Sayeem Uddin
	2020-10
发表期刊	INFECTION GENETICS AND EVOLUTION
ISSN	1567-1348
EISSN	1567-7257
摘要	SARS-CoV-2, a new coronavirus strain responsible for COVID-19, has emerged in Wuhan City, China, and continuing its global pandemic nature. The availability of the complete gene sequences of the virus helps to know about the origin and molecular characteristics of this virus. In the present study, we performed bioinformatic analysis of the available gene sequence data of SARS-CoV-2 for the understanding of evolution and molecular characteristics and immunogenic resemblance of the circulating viruses. Phylogenetic analysis was performed for four types of representative viral proteins (spike, membrane, envelope and nucleoprotein) of SARS-CoV-2, HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1, MERS-CoV, HKU4, HKU5 and BufCoVHKU26. The findings demonstrated that SARS-CoV-2 exhibited convergent evolutionary relation with previously reported SARS-CoV. It was also depicted that SARS-CoV-2 proteins were highly similar and identical to SARSCoV proteins, though proteins from other coronaviruses showed a lower level of resemblance. The cross-checked conservancy analysis of SARS-CoV-2 antigenic epitopes showed significant conservancy with antigenic epitopes derived from SARS-CoV. Descriptive epidemiological analysis on several epidemiological indices was performed on available epidemiological outbreak information from several open databases on COVID-19 (SARS-CoV-2). Satellite-derived imaging data have been employed to understand the role of temperature in the environmental persistence of the virus. Findings of the descriptive analysis were used to describe the global impact of newly emerged SARS-CoV-2, and the risk of an epidemic in Bangladesh.
关键词	SARS-CoV-2 Evolutionary analysis Temperature Descriptive epidemiology Pandemic Bangladesh
DOI	10.1016/j.meegid.2020.104440
WOS关键词	OUTBREAK ; MODELS ; HEALTH ; WATER ; RISK
WOS研究方向	Infectious Diseases
WOS类目	Infectious Diseases
出版者	ELSEVIER
引用统计
文献类型	期刊论文
专题	新冠肺炎循证社会科学证据集成
作者单位	Sylhet Agr Univ
推荐引用方式 GB/T 7714	Uddin, Md Bashir,Hasan, Mahmudul,Imran, Md Abdus Shukur,et al. Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective[J]. INFECTION GENETICS AND EVOLUTION,2020.
APA	Uddin, Md Bashir,Hasan, Mahmudul,Imran, Md Abdus Shukur,Harun-Al-Rashid, Ahmed,Ahsan, Md Irtija,&Ahmed, Syed Sayeem Uddin.(2020).Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective.INFECTION GENETICS AND EVOLUTION.
MLA	Uddin, Md Bashir,et al."Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective".INFECTION GENETICS AND EVOLUTION (2020).