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| Weathering the Cytokine Storm in COVID-19: Therapeutic Implications | |
| Iannaccone, Giulia1; Scacciavillani, Roberto1; Del Buono, Marco Giuseppe1; Camilli, Massimiliano1; Crea, Filippo1,6; Massetti, Massimo1,6; Ronco, Claudio2,3; Lavie, Carl J.4; Abbate, Antonio5; Aspromonte, Nadia6 | |
| 2020-09 | |
| 发表期刊 | CARDIORENAL MEDICINE
 |
| ISSN | 1664-3828 |
| EISSN | 1664-5502 |
| 摘要 | Background:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged in Wuhan, Hubei-China, as responsible for the coronavirus disease 2019 (COVID-19) and then spread rapidly worldwide. While most individuals remain asymptomatic or develop only mild symptoms, approximately 5% develop severe forms of COVID-19 characterized by acute respiratory distress syndrome (ARDS) and multiple-organ failure (MOF) that usually require intensive-care support and often yield a poor prognosis.Summary:The pathophysiology of COVID-19 is far from being completely understood, and the lack of effective treatments leads to a sense of urgency to develop new therapeutic strategies based on pathophysiological assumptions. The exaggerated cytokine release in response to viral infection, a condition known as cytokine release syndrome (CRS) or cytokine storm, is emerging as the mechanism leading to ARDS and MOF in COVID-19, thus endorsing the hypothesis that properly timed anti-inflammatory therapeutic strategies could improve patients' clinical outcomes and prognosis.Key Messages:The objective of this article is to explore and comment on the potential role of the promising immunomodulatory therapies using pharmacological and nonpharmacological approaches to overcome the dysregulated proinflammatory response in COVID-19. |
| 关键词 | Cytokine storm COVID-19 Therapy |
| DOI | 10.1159/000509483 |
| WOS关键词 | RESPIRATORY SYNDROME-CORONAVIRUS ; BLOOD PURIFICATION ; TNF-ALPHA ; INTERLEUKIN-1 ; INFLAMMASOME ; MANAGEMENT ; MORTALITY ; INFECTION ; PROTEIN ; SEPSIS |
| WOS研究方向 | Cardiovascular System & Cardiology ; Urology & Nephrology |
| WOS类目 | Cardiac & Cardiovascular Systems ; Urology & Nephrology |
| 出版者 | KARGER |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 专题 | 新冠肺炎 循证社会科学证据集成 |
| 作者单位 | 1.Univ Cattolica Sacro Cuore; 2.Univ Padua; 3.San Bortolo Hosp; 4.Univ Queensland; 5.Virginia Commonwealth Univ; 6.Fdn Policlin Univ A Gemelli IRCCS |
| 推荐引用方式 GB/T 7714 | Iannaccone, Giulia,Scacciavillani, Roberto,Del Buono, Marco Giuseppe,et al. Weathering the Cytokine Storm in COVID-19: Therapeutic Implications[J]. CARDIORENAL MEDICINE,2020. |
| APA | Iannaccone, Giulia.,Scacciavillani, Roberto.,Del Buono, Marco Giuseppe.,Camilli, Massimiliano.,Crea, Filippo.,...&Aspromonte, Nadia.(2020).Weathering the Cytokine Storm in COVID-19: Therapeutic Implications.CARDIORENAL MEDICINE. |
| MLA | Iannaccone, Giulia,et al."Weathering the Cytokine Storm in COVID-19: Therapeutic Implications".CARDIORENAL MEDICINE (2020). |
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| Iannaccone-2020-Weat（516KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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