Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy

doi:10.1016/j.scitotenv.2020.140278

	Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy
	Filippini, Tommaso 1; Vinceti, Marco 1,3; Rothman, Kenneth J.2,3; Goffi, Alessia 4; Ferrari, Fabrizio 4; Maffeis, Giuseppe 4; Orsini, Nicola 5
	2020-10
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
EISSN	1879-1026
摘要	Following the outbreak of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) last December 2019 in China, Italywas the first European country to be severely affected, with the first local case diagnosed on 20 February 2020. The virus spread quickly, particularly in the North of Italy, with three regions (Lombardy, Veneto and Emilia-Romagna) being the most severely affected. These three regions accounted for >80% of SARS-CoV-2 positive cases when the tight lockdownwas established (March 8). These regions include one of Europe's areas of heaviest air pollution, the Po valley. Air pollution has been recently proposed as a possible risk factor of SARS-CoV-2 infection, due to its adverse effect on immunity and to the possibility that polluted air may even carry the virus. We investigated the association between air pollution and subsequent spread of the SARS-CoV-2 infection within these regions. We collected NO2 tropospheric levels using satellite data available at the European Space Agency before the lockdown. Using a multivariable restricted cubic spline regression model, we compared NO2 levels with SARS-CoV-2 infection prevalence rate at different time points after the lockdown, namely March 8, 22 and April 5, in the 28 provinces of Lombardy, Veneto and Emilia-Romagna. We found little association of NO2 levelswith SARS-CoV-2 prevalence up to about 130 mu mol/m(2), while a positive association was evident at higher levels at each timepoint. Notwithstanding the limitations of the use of aggregated data, these findings lend some support to the hypothesis that high levels of air pollution may favor the spread of the SARS-CoV-2 infection. (C) 2020 Elsevier B.V. All rights reserved.
关键词	Covid-19 Coronavirus Air pollution Nitrogen dioxide Sentinel-5P Public health
DOI	10.1016/j.scitotenv.2020.140278
WOS关键词	BRONCHIAL EPITHELIAL-CELLS ; POLLUTION PARTICULATE MATTER ; AIR-POLLUTION ; EXPOSURE ; RESPONSES ; COVID-19 ; IMPACT ; NO2 ; ANTIOXIDANT ; TEMPERATURE
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
出版者	ELSEVIER
引用统计
文献类型	期刊论文
专题	新冠肺炎循证社会科学证据集成
作者单位	1.Univ Modena & Reggio Emilia; 2.RTI Hlth Solut; 3.Boston Univ; 4.Terraria; 5.Karolinska Inst
推荐引用方式 GB/T 7714	Filippini, Tommaso,Vinceti, Marco,Rothman, Kenneth J.,et al. Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020.
APA	Filippini, Tommaso.,Vinceti, Marco.,Rothman, Kenneth J..,Goffi, Alessia.,Ferrari, Fabrizio.,...&Orsini, Nicola.(2020).Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy.SCIENCE OF THE TOTAL ENVIRONMENT.
MLA	Filippini, Tommaso,et al."Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy".SCIENCE OF THE TOTAL ENVIRONMENT (2020).