Immune-epidemiological parameters of the novel coronavirus - a perspective

doi:10.1080/1744666X.2020.1750954

	Immune-epidemiological parameters of the novel coronavirus - a perspective
	Saghazadeh, Amene 1,2; Rezaei, Nima 1,2
	2020-04
发表期刊	EXPERT REVIEW OF CLINICAL IMMUNOLOGY
ISSN	1744-666X
EISSN	1744-8409
摘要	Introduction: At the end of 2019, Wuhan, a city in China with a population of about 11 million, witnessed the outbreak of unusual pneumonia. As of 29 March 2020, the disease has spread to more 199 countries and territories worldwide. The 2019 novel coronavirus, 2019-nCoV, is known as the probable causative agent of the illness. Areas covered: Here, the epidemiological dynamics of the coronavirus disease 2019 (COVID-19) that stand in close relation to distinct immunogenetic characters of the pathogen are discussed, to understand the ability and inability of the immune system in combatting COVID-19. Expert opinion: The elderly population is at increased risk of developing and dying from COVID-19. Comorbidity is present in more than 30% of cases with COVID-19. Except for less than 1% of the total, a chronic condition has been found in all cases that died from COVID-19. Men are more than 1.5 times more likely to die from COVID-19. Evidence links aging to cytokine dysregulation and T-cell repertoire reduction, male population to relatively reduced anti-viral immunity, and COVID-19-related comorbidities to hyper inflammation. The transmission of COVID-19 is influenced by the host-related factors that are known to be associated with immune dysregulation.
关键词	Novel coronavirus 2019-nCoV SARS-CoV2 immune-epidemiology COVID-19
DOI	10.1080/1744666X.2020.1750954
WOS关键词	TOLL-LIKE RECEPTORS ; SARS CORONAVIRUS ; INNATE ; RESPONSES ; TEMPERATURE ; REMDESIVIR ; INFECTION ; CHILDREN
WOS研究方向	Immunology
WOS类目	Immunology
出版者	TAYLOR & FRANCIS LTD
引用统计	被引频次：154[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
专题	新冠肺炎循证社会科学证据集成
作者单位	1.Univ Tehran Med Sci; 2.USERN
推荐引用方式 GB/T 7714	Saghazadeh, Amene,Rezaei, Nima. Immune-epidemiological parameters of the novel coronavirus - a perspective[J]. EXPERT REVIEW OF CLINICAL IMMUNOLOGY,2020.
APA	Saghazadeh, Amene,&Rezaei, Nima.(2020).Immune-epidemiological parameters of the novel coronavirus - a perspective.EXPERT REVIEW OF CLINICAL IMMUNOLOGY.
MLA	Saghazadeh, Amene,et al."Immune-epidemiological parameters of the novel coronavirus - a perspective".EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2020).

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